Mitochondrial carrier homolog 1 (Mtch1) antibodies in neuro-Beh?et's disease
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- 作者：Bur?ak Vural ; El?in ?ehito?lu ; Filiz ?avu? ; Nazl? Yal??nkaya ; Hazal Haytural ; Melike K¨¹?¨¹kerden ; Canan Ulusoy ; Elif U?urel ; Selin Turan ; Leyla Bulut ; Recai T¨¹rko?lu ; Erking¨¹l Shugaiv ; Murat K¨¹rt¨¹nc¨¹ ; ?¨¹kr¨¹ Atakan ; Ali O. G¨¹re ; Ahmet G¨¹l ; Mefkure Eraksoy ; G¨¹l?en Akman-Demir ; Erdem T¨¹z¨¹n
- 关键词：Behç ; et's disease ; Neuro-Behç ; et's disease ; Anti-neuronal antibody ; Mitochondrial carrier homolog 1 ; Antibody ; Autoimmunity
- 刊名：Journal of Neuroimmunology
- 出版年：2013
- 出版时间：15 October, 2013
- 年：2013
- 卷：263
- 期：1-2
- 页码：139-144
- 全文大小：695 K
文摘
Efforts for the identification of diagnostic autoantibodies for neuro-Behcet's disease (NBD) have failed. Screening of NBD patients' sera with protein macroarray identified mitochondrial carrier homolog 1 (Mtch1), an apoptosis-related protein, as a potential autoantigen. ELISA studies showed serum Mtch1 antibodies in 68 of 144 BD patients with or without neurological involvement and in 4 of 168 controls corresponding to a sensitivity of 47.2 % and specificity of 97.6 % . Mtch1 antibody positive NBD patients had more attacks, increased disability and lower serum nucleosome levels. Mtch1 antibody might be involved in pathogenic mechanisms of NBD rather than being a coincidental byproduct of autoinflammation.