Glycolysis inhibition as a cancer treatment and its role in an anti-tumour immune response

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• 作者：Kheshwant S. Gill^a ; ^b ; Philana Fernandes^a ; Tracey R. O'Donovan^a ; Sharon L. McKenna^a ; Kishore K. Doddakula^b ; Derek G. Power^a ; ^c ; Declan M. Soden^a ; Patrick F. Forde^a ; ^{p.forde@ucc.ie" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Glycolysis ; Glycolytic modulator ; Immune-metabolic interaction ; Electroporation
• 刊名：Biochimica et Biophysica Acta (BBA)-Reviews on Cancer
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：1866
• 期：1
• 页码：87-105
• 全文大小：1014 K

文摘

Increased glycolysis is the main source of energy supply in cancer cells that use this metabolic pathway for ATP generation. Altered energy metabolism is a biochemical fingerprint of cancer cells that represents one of the “hallmarks of cancer”. The immune system can prevent tumour growth by eliminating cancer cells but this editing process ultimately results in poorly immunogenic cells remaining allowing for unchallenged tumour growth. In this review we look at the glycolysis pathway as a target for cancer treatments. We also examine the interplay between the glycolysis modulation and the immune response as an anti-cancer therapy.