- 作者：Elisa Scalco ; Claudio Fiorino ; Giovanni Mauro Cattaneo ; Giuseppe Sanguineti ; Giovanna Rizzo
- 关键词：Texture analysis ; Fractal dimension ; Parotid gland shrinkage ; Adaptive radiotherapy
- 刊名：Radiotherapy and Oncology
- 出版年：December, 2013
- 年：2013
- 卷：109
- 期：3
- 页码：384-387
- 全文大小：385 K
Background and purpose
During radiotherapy (RT) for head-and-neck cancer, parotid glands undergo significant anatomic, functional and structural changes which could characterize pre-clinical signs of an increased risk of xerostomia. Texture analysis is proposed to assess structural changes of parotids induced by RT, and to investigate whether early variations of textural parameters (such as mean intensity and fractal dimension) can predict parotid shrinkage at the end of treatment.Material and methods
Textural parameters and volumes of 42 parotids from 21 patients treated with intensity-modulated RT for nasopharyngeal cancer were extracted from CT images. To individuate which parameters changed during RT, a Wilcoxon signed-rank test between textural indices (first and second RT week; first and last RT week) was performed. Discriminant analysis was applied to variations of these parameters in the first two weeks of RT to assess their power in predicting parotid shrinkage at the end of RT.
Results
A significant decrease in mean intensity (1.7 HU and 3.8 HU after the second and last weeks, respectively) and fractal dimension (0.016 and 0.021) was found. Discriminant analysis, based on volume and fractal dimension, was able to predict the final parotid shrinkage (accuracy of 71.4%).
Conclusion
Textural features could be used in combination with volume to characterize structural modifications on parotid glands and to predict parotid shrinkage at the end of RT.