Breaking the DNA damage response to improve cervical cancer treatment
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- 作者：Hylke W. Wieringaa ; b ; Ate G.J. van der Zeeb ; Elisabeth G.E. de Vriesa ; Marcel A.T.M. van Vugta ; m.vugt@umcg.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cervical cancer ; Radiotherapy ; Cisplatin ; DNA damage response ; DDR-inhibitors
- 刊名：Cancer Treatment Reviews
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：42
- 期：Complete
- 页码：30-40
- 全文大小：503 K
文摘
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Combined chemoradiotherapy is standard of care for advanced cervical cancer.
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Chemoradiotherapy introduces DNA damage in tumor cells to induce cell death.
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Tumor cells activate the ‘DNA damage response’ to repair therapy-induced DNA damage.
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HPV partially impairs the cellular response to DNA damage in cervical cancer cells.
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Therapeutic targeting of residual DDR could improve cervical cancer treatment.