Chronic restraint stress during early Theiler's virus infection exacerbates the subsequent demyelinating disease in SJL mice: II. CNS disease severity

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• 作者：Erin E. Young ; Amy N. Sieve ; Elisabeth G. Vichaya ; Luis M. Carcoba ; Colin R. Young ; Andrew Ambrus ; Ralph Storts ; C. Jane R. Welsh ; Mary W. Meagher
• 关键词：Multiple sclerosis ; Theiler's murine encephalomyelitis virus ; Demyelination ; Inflammation ; Axonal degeneration ; CNS disease severity
• 刊名：Journal of Neuroimmunology
• 出版年：2010
• 出版时间：30 March 2010
• 年：2010
• 卷：220
• 期：1-2
• 页码：79-89
• 全文大小：4073 K

文摘

Theiler's murine encephalomyelitis virus (TMEV) infection is a well-characterized model of multiple sclerosis (MS). Previous research has shown that chronic restraint stress (RS) during early TMEV infection exacerbates behavioral signs of the disease. The present data suggest that RS-induced increases in CNS inflammation, demyelination, and axonal degeneration may underlie this exacerbation. In addition, we report that males exhibit greater CNS inflammation and higher numbers of demyelinating lesions while females show greater susceptibility to RS-induced exacerbation. These findings indicate that RS during early TMEV infection increases CNS lesion formation during the late phase and suggest that the effects of RS are sex-dependent.