Insights on diagnosis of oral cavity pathologies by infrared spectroscopy: A review

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• 作者：Elisabetta Giorgini ; Paolo Balercia ; Carla Conti ; Paolo Ferraris ; Simona Sabbatini ; Corrado Rubini ; Giorgio Tosi
• 关键词：Oral cavity pathologies ; FT-IR microspectroscopy ; Head and neck cancer ; Multivariate analysis
• 刊名：Journal of Molecular Structure
• 出版年：2013
• 出版时间：5 November, 2013
• 年：2013
• 卷：1051
• 期：Complete
• 页码：226-232
• 全文大小：1060 K

文摘

Fourier-Transform Infrared microspectroscopy, a largely used spectroscopic technique in basic and industrial researches, offers the possibility to analyze the vibrational features of molecular groups within a variety of environments. In the bioclinical field, and, in particular, in the study of cells, tissues and biofluids, it could be considered a supporting objective technique able to characterize the biochemical processes involved in relevant pathologies, such as tumoral diseases, highlighting specific spectral markers associable with the principal biocomponents (proteins, lipids and carbohydrates). In this article, we review the applications of infrared spectroscopy to the study of tumoral diseases of oral cavity compartments with the aim to improve understanding of biological processes involved during the onset of these lesions and to afford to an early diagnosis. Spectral studies on mouth, salivary glands and oral cystic lesions, objectively discriminate normal from dysplastic and cancer states characterizing also the grading.