Facile and convenient synthesis of aryl hydrazines via copper-catalyzed C-N cross-coupling of aryl halides and hydrazine hydrate

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• 作者：Daria V. Kurandina ; ^{dashakura@gmail.com" class="auth_mail} ; Eugene V. Eliseenkov ; Petr V. Ilyin ; Vadim P. Boyarskiy
• 关键词：C&ndash ; N Cross-coupling reaction ; Copper catalysis ; Hydrazine hydrate ; Aryl bromides ; Preparation of aryl hydrazines
• 刊名：Tetrahedron
• 出版年：1 July 2014
• 年：2014
• 卷：70
• 期：26
• 页码：4043-4048
• 全文大小：706 K

文摘

An efficient and convenient method for the synthesis of aryl hydrazines has been developed via copper-catalyzed cross-coupling of aryl bromides and hydrazine with a readily accessible ligand and water as a solvent. The multigram scale procedure is applicable to aryl bromides bearing both moderately electron-donating and electron-withdrawing substituents in the aromatic nucleus. No column chromatography is required to obtain aryl hydrazine hydrochlorides in good yields.