The involvement of serotonergic system in the antidepressant effect of zinc in the forced swim test
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- 作者：Bernadeta Szewczyk ; Ewa Poleszak ; Piotr Wlaź ; Andrzej Wró ; bel ; Eliza Blicharska ; Agnieszka Cichy ; Mał ; gorzata Dybał ; a ; Agata Siwek ; Lucyna Pomierny-Chamioł ; o ; Anna Piotrowska
- 关键词：Antidepressants ; FST ; pCPA ; Ritanserin ; WAY 100635 ; Zinc
- 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
- 出版年：2009
- 出版时间：17 March 2009
- 年：2009
- 卷：33
- 期：2
- 页码：323-329
- 全文大小：467 K
文摘
Recent preclinical data indicated the antidepressant-like activity of zinc in different tests and models of depression. The present study investigates the involvement of the serotonergic system in zinc activity in the forced swim test (FST) in mice and rats. The combined treatment of sub-effective doses of zinc (hydroaspartate, 2.5 mg Zn/kg) and citalopram (15 mg/kg), fluoxetine (5 mg/kg) but not with reboxetine (2.5 mg/kg) significantly reduces the immobility time in the FST in mice. These treatments had no influence on the spontaneous locomotor activity. Moreover, while the antidepressant-like effect of zinc (5 mg/kg) in the FST was significantly blocked by pretreatment with inhibitor of serotonin synthesis, p-chlorophenylalanine (pCPA, 3 × 200 mg/kg), 5HT-2A/C receptor antagonist, ritanserin (4 mg/kg) or 5HT-1A receptor antagonist, WAY 1006335 (0.1 mg/kg), the zinc-induced reduction in the locomotor activity was not affected by these serotonin modulator agents. These results indicate the specific involvement of the serotonergic system in antidepressant but not the motion behavior of zinc in mice. Also, an increase in the swimming but not climbing parameter of the rat FST observed following zinc administration (2.5 and 5 mg Zn/kg) indicates the serotonin pathway participation. This present data indicates that the antidepressant-like activity of zinc observed in the FST involves interaction with the serotonergic system.