Blunted mGluR Activation Disinhibits Striatopallidal Transmission in Parkinsonian Mice

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• 作者：Qiaoling Cui¹ ; Jason E. Pitt¹ ; Arin Pamukcu¹ ; Jean-Francois Poulin² ; Omar S. Mabrouk³ ; Michael P. Fiske¹ ; Isabel B. Fan¹ ; Elizabeth C. Augustine¹ ; Katherine A. Young¹ ; Robert T. Kennedy³ ; Rajeshwar Awatramani² ; C. Savio Chan¹ ; ⁴ ; ^{saviochan@gmail.com}
• 关键词：basal ganglia ; striatum ; external globus pallidus ; 6-OHDA ; GCaMP ; iGluSnFR ; patch-clamp ; glutamate homeostasis ; tyrosine hydroxylase ; astrocytes
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：22 November 2016
• 年：2016
• 卷：17
• 期：9
• 页码：2431-2444
• 全文大小：4359 K
• 卷排序：17

文摘

An ambient level of glutamate is maintained in the GPe ex vivo GPe astrocytes gate striatopallidal transmission via presynaptic group II mGluRs GPe astrocytes display altered glutamate homeostasis in models of PD Reduced mGluR activation leads to overactive striatopallidal transmission in PD