Alcohol exposure differentially effects anti-tumor immunity in females by altering dendritic cell function

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• 作者：Matthew G. Thompson^a ; Flor Navarro^a ; Lennox Chitsike^a ; Luis Ramirez^a ; Elizabeth J. Kovacs^a ; ^b ; Stephanie K. Watkins^a ; ^{swatkins1@luc.edu}
• 关键词：Anti-tumor immunity ; Sex ; Alcohol ; Dendritic cell ; Cytotoxic T cell
• 刊名：Alcohol
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：57
• 期：Complete
• 页码：1-8
• 全文大小：1527 K
• 卷排序：57

文摘

Alcohol differentially stimulates dendritic cells in males and females. Alcohol promotes reduced immune stimulatory capacity of female DC. Female DC treated with alcohol have reduced IL-12 production. Tumor Ag-specific T cells stimulated by female DC previously exposed to alcohol have reduced anti-tumor effector functions.