Effect of channel-induced shear on biologics during ultrafiltration/diafiltration (UF/DF)
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- 作者：Abhiram Arunkumar ; Nripen Singh ; Nripen.singh@bms.com" class="auth_mail" title="E-mail the corresponding author ; Elizabeth G. Schutsky ; Michael Peck ; Ryan K. Swanson ; Michael C. Borys ; Zheng Jian Li
- 关键词：Ultrafiltration/diafiltration ; Cassette feed screens ; Shear ; Biologic ; Drug substance ; Product quality
- 刊名：Journal of Membrane Science
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：514
- 期：Complete
- 页码：671-683
- 全文大小：1578 K
文摘
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First to compare hydraulics of different screened channels for four biologic assets.
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First to correlate biologic product quality with screen channel type.
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Presents process development and product quality data for lightly suspended screen cassettes.
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Four techniques used to confirm findings for four biologic assets.
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High concentration ultrafiltration data presented for different screens for biologics.