Acyl CoA synthetase 5 (ACSL5) ablation in mice increases energy expenditure and insulin sensitivity and delays fat absorption
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- 作者：Thomas A. Bowman1 ; thomas.bowman@tufts.edu" class="auth_mail" title="E-mail the corresponding author ; Kayleigh R. O'Keeffe1 ; kokeeffe@live.unc.edu" class="auth_mail" title="E-mail the corresponding author ; Theresa D'Aquila3 ; tdaquila@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Qing Wu Yan1 ; qing-wu.yan@tufts.edu" class="auth_mail" title="E-mail the corresponding author ; John D. Griffin1 ; john.griffin@tufts.edu" class="auth_mail" title="E-mail the corresponding author ; Elizabeth A. Killion1 ; elizabeth.killion@tufts.edu" class="auth_mail" title="E-mail the corresponding author ; Deanna M. Salter1 ; deanna.salter@tufts.edu" class="auth_mail" title="E-mail the corresponding author ; Douglas G. Mashek2 ; dmashek@umn.edu" class="auth_mail" title="E-mail the corresponding author ; Kimberly K. Buhman3 ; kbuhman@purdue.edu" class="auth_mail" title="E-mail the corresponding author ; Andrew S. Greenberg1 ; andrew.greenberg@tufts.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Dietary fat absorption ; Acyl-CoA ; ACSL ; Intestine ; Liver ; FGF21
- 刊名：Molecular Metabolism
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：5
- 期：3
- 页码：210-220
- 全文大小：2169 K
文摘
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Role of acyl CoA synthetase 5 (ACSL5) in systemic metabolism was studied in an ACSL5 deficient mouse.
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ACSL5 deficiency reduced total ACSL activity in liver, intestine, and brown adipose tissue.
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ACSL5 deficient mice had increased hepatic and circulating FGF21 expression and energy expenditure.
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ACSL5 deficient mice demonstrated delayed triglyceride absorption.