The Trypanosoma cruzi Surface, a Nanoscale Patchwork Quilt

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• 作者：Juan Mucci¹ ; ² ; André ; s B. Lantos¹ ; ² ; Carlos A. Buscaglia¹ ; Marí ; a Susana Leguizamó ; n¹ ; Oscar Campetella¹ ; ^{oscar@unsam.edu.ar} ; ^{ocampetella@gmail.com}
• 关键词：membrane domains ; membrane vesicle ; mucin ; sialic acids ; trans-sialidase
• 刊名：Trends in Parasitology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：33
• 期：2
• 页码：102-112
• 全文大小：2740 K
• 卷排序：33

文摘

The Trypanosoma cruzi trypomastigote membrane provides a major protective role against mammalian host-derived defense mechanisms while allowing the parasite to interact with different cell types and trigger pathogenesis. This surface has been historically appreciated as a rather unstructured ‘coat’, mainly consisting of a continuous layer of glycolipids and heavily O-glycosylated mucins, occasionally intercalated with different developmentally regulated molecules displaying adhesive and/or enzymatic properties. Recent findings, however, indicate that the trypomastigote membrane is made up of multiple, densely packed and discrete 10–150 nm lipid-driven domains bearing different protein composition; hence resembling a highly organized ‘patchwork quilt’ design. Here, we discuss different aspects underlying the biogenesis, assembly, and dynamics of this cutting-edge fashion outfit, as well as its functional implications.