kurly (kur) mutants exhibit defects characteristic of motile cilia dysfunction
c21orf59 is mutated in kur and is needed for dynein arm localization/cilia motility
CRISPR/Cas9 with homologous recombination in Xenopus shows C21orf59 regulates PCP
C21orf59 interacts with various PCP components to correctly polarize motile cilia