Elongation factor-1A1 is a novel substrate of the protein phosphatase 1-TIMAP complex
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- 作者：Anita Boratkó ; Margit Pé ; ter ; Zsó ; fia Thalwieser ; Előd Ková ; cs ; Csilla Csortos ; csortos@med.unideb.hu" class="auth_mail" title="E-mail the corresponding author
- 关键词：BPAEC ; bovine pulmonary artery endothelial cell ; EC ; endothelial cell ; ECIS ; electric cell-substrate impedance sensing ; eEF1A1 ; elongation factor 1A1 ; ERM ; ezrin-radixin-moesin ; GST ; glutathione S-transferase ; HPAEC ; human pulmonary artery endothelial cells ; LAMR1 ; laminin receptor-1 ; LC&ndash ; MS/MS ; liquid chromatography-tandem mass spectrometry ; MYPT ; myosin phosphatase targeting subunit ; RACK1 ; receptor for activated C kinase 1 ; ROCK ; Rho-associated protein kinase ; PP1 ; protein phosphatase 1
- 刊名：International Journal of Biochemistry and Cell Biology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：69
- 期：Complete
- 页码：105-113
- 全文大小：1711 K
文摘
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Elongation factor 1A1 interacts with TIMAP-protein phosphatase 1 (PP1) complex.
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TD-NEM-like motif in TIMAP is crucial in the interaction.
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TIMAP affects membrane localization of the elongation factor in endothelial cells.
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ROCK phosphorylated elongation factor 1A1 is a substrate for TIMAP-PP1.
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Elongation factor 1A1 has an effect on endothelial cell spreading and attachment.