Prenatal low-dose methylmercury exposure impairs neurite outgrowth and synaptic protein expression and suppresses TrkA pathway activity and eEF1A1 expression in the rat cerebellum
详细信息 查看全文
- 作者：Masatake Fujimuraa ; fujimura@nimd.go.jp" class="auth_mail" title="E-mail the corresponding author ; Fusako Usukib ; Jinping Chengc ; Wenchang Zhaoc
- 关键词：MeHg ; methylmercury ; NGF ; nerve growth factor ; BDNF ; brain-derived neurotrophic factor ; NT-3 ; neurotrophin-3 ; Trk ; tropomyosin receptor kinase ; eEF ; eukaryotic elongation factor ; p70S6K ; p70 S6 kinase ; mTOR ; mammalian target of rapamycin ; siRNA ; small interfering RNA ; Hg ; mercury ; SPP ; synaptophysin ; IP3R1 ; inositol 1 ; 4 ; 5-trisphosphate receptor type 1 ; GD ; gestation day ; PND ; postnatal day ; PSD95 ; postsynaptic density protein 95 ; SNAP25 ; synaptosomal-associated protein 25
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：298
- 期：Complete
- 页码：1-8
- 全文大小：1267 K
文摘
- •
Prenatal exposure to MeHg decreased postnatal expression of synaptic proteins.
- •
MeHg exposure also reduced neurite outgrowth postnatally.
- •
Suppression of the TrkA pathway and eEF1A1 expression was induced by MeHg exposure.
- •
eEF1A1 knockdown impaired neurite outgrowth and synaptic protein expression.