The RNA Polymerase II CTD: The Increasing Complexity of a Low-Complexity Protein Domain
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- 作者：Cé ; lia Jeronimo1 ; Pierre Collin1 ; Franç ; ois Robert1 ; 2 ; francois.robert@ircm.qc.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：RNAPII ; RNA polymerase II ; CTD ; RNAPII C-terminal domain ; PIC ; pre-initiation complex ; as ; analog-sensitive ; AA ; anchor-away ; ChIP ; chromatin immunoprecipitation ; NELF ; negative elongation factor ; DSIF ; DRB-sensitivity-inducing factor ; ERK2 ; extracellular signal-regulated kinase 2 ; PRC2 ; polycomb repressive complex 2 ; DYRK1A ; dual specificity tyrosine-regulated kinase 1 ; A ; pA ; polyadenylation ; CPF ; cleavage and polyadenylation factor ; CTR ; Spt5 C-terminal region
- 刊名：Journal of Molecular Biology
- 出版年：2016
- 出版时间：19 June 2016
- 年：2016
- 卷：428
- 期：12
- 页码：2607-2622
- 全文大小：723 K
文摘
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CTD Ser5 phosphorylation by CDK7/Kin28 allows promoter escape and enables pausing.
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Dephosphorylation of CTD Ser5 involves several phosphatases.
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CDK12 likely has specialized, cell type-specific and/or gene-specific roles in human.
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CTD Tyr1 phosphorylation has different distribution patterns, and most likely different functions, in yeast and metazoans.
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Some RNA processing factors feedback on CTD phosphorylation.