Newly emerging C group enteroviruses may elude diagnosis due to a divergent 5鈥?UTR

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• 作者：Jan Richter ; Christina Tryfonos ; Christakis Panagiotou ; Elpiniki Nikolaou ; Maria Koliou ; Christina Christodoulou
• 关键词：Enteroviruses ; Epidemiology ; Real-Time RT-PCR ; Emerging viruses ; Cyprus
• 刊名：International Journal of Infectious Diseases
• 出版年：December, 2013
• 年：2013
• 卷：17
• 期：12
• 页码：e1245-e1248
• 全文大小：449 K

文摘

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Summary

Human enterovirus (HEV) 105 was first reported in 2012 in children from Peru and Congo. We report on the identification of a novel HEV-C105 strain in a pediatric patient in Cyprus with an upper respiratory tract infection. Sequence alignment and phylogenetic analysis of 5鈥?UTRs of all known HEVs revealed that our isolate belongs to a group of recently identified HEV-C viruses exhibiting a 5鈥?UTR distinct from all other previously known enteroviruses. This has important implications for diagnosis, as this region is the primary target for diagnostic assays. Increased awareness in laboratories may thus increase the rate of detection of enteroviruses belonging to this subspecies, or lead to the discovery of further genotypes.