Pomegranate protects liver against cecal ligation and puncture-induced oxidative stress and inflammation in rats through TLR4/NF‐κB pathway inhibition
详细信息 查看全文
- 作者：Mirhan N. Makleda ; mirhan_makled@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Mohammed S. El-Awadya ; Rania R. Abdelaziza ; Nadia Atwanb ; Emma T. Gunsc ; Nariman M. Gameila ; Ahmed B. Shehab El-Dind ; Elsayed M. Ammara
- 关键词：CLP ; cecal ligation and puncture ; GSH ; reduced glutathione ; LDH ; lactate dehydrogenase ; MDA ; malondialdehyde ; MPO ; myeloperoxidase ; κB ; nuclear factor-κB ; SOD ; superoxide dismutase ; TLR ; toll-like receptor-4 ; tumor necrosis factor-α
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：43
- 期：Complete
- 页码：182-192
- 全文大小：3015 K
文摘
- •
Pomegranate has antiinflammatory and antioxidant effects on CLP-acute liver injury.
- •
Pomegranate has ability to inhibit TLR4/NF‐κB pathway and neutrophil infiltration.
- •
Pomegranate has ability to modulate lipid peroxidation and antioxidants levels.