Xyolide, a bioactive nonenolide from an Amazonian endophytic fungus, Xylaria feejeensis

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• 作者：Ezra G. Baraban ; Jesse B. Morin ; Gillian M. Phillips ; Andrew J. Phillips ; Scott A. Strobel ; Jo H ; elsman
• 关键词：OUOHBCJNWADUGG-KBDQXCAPSA-N
• 刊名：Tetrahedron Letters
• 出版年：2013
• 出版时间：31 July, 2013
• 年：2013
• 卷：54
• 期：31
• 页码：4058-4060
• 全文大小：582 K

文摘

Endophytes isolated from tropical plants represent a largely untapped reservoir of bioactive secondary metabolites. We screened a library of fungal endophyte extracts for inhibition of the plant pathogen, Pythium ultimum, and purified an active compound using bioassay-guided fractionation. A new nonenolide, (4S,7S,8S,9R)-4-O-succinyl-7,8-dihydroxy-9-heptyl-nonen-9-olide, was isolated and named xyolide. The structure was elucidated by a combination of 1D and 2D NMR methods and the absolute configuration was determined by exciton-coupled circular dichroism. The MIC of xyolide against P. ultimum was 425 ¦ÌM.