Bioaccessibility of metals in alloys: Evaluation of three surrogate biofluids
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- 作者：Wendy E. Hillwalker ; Kim A. Anderson
- 关键词：Stainless steel ; In vitro ; Residence time ; Alloy dissolution ; Bioavailable ; Biological monitoring ; Dust exposure ; Occupational hazard ; Bio-elution
- 刊名：Environmental Pollution
- 出版年：February, 2014
- 年：2014
- 卷：185
- 期：Complete
- 页码：52-58
- 全文大小：328 K
文摘
Bioaccessibility in聽vitro tests measure the solubility of materials in surrogate biofluids. However, the lack of uniform methods and the effects of variable test parameters on material solubility limit interpretation. One aim of this study was to measure and compare bioaccessibility of selected economically important alloys and metals in surrogate physiologically based biofluids representing oral, inhalation and dermal exposures. A second aim was to experimentally test different biofluid formulations and residence times in聽vitro. A third aim was evaluation of dissolution behavior of alloys with in聽vitro lung and dermal biofluid surrogates. This study evaluated the bioaccessibility of sixteen elements in six alloys and 3 elemental/metal powders. We found that the alloys/metals, the chemical properties of the surrogate fluid, and residence time all had major impacts on metal solubility. The large variability of bioaccessibility indicates the relevancy of assessing alloys as toxicologically distinct relative to individual metals.