High-throughput analysis of 19 endogenous androgenic steroids by ultra-performance convergence chromatography tandem mass spectrometry
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- 作者：Jonathan L. Quansona ; Marietjie A. Standera ; b ; Elzette Pretoriusa ; Carl Jenkinsonc ; Angela E. Taylorc ; 1 ; Karl-Heinz Storbecka ; 1 ; storbeck@sun.ac.za" class="auth_mail" title="E-mail the corresponding author
- 关键词：3α-adiol ; 5α-androstane-3α ; 17β-diol ; 5α-dione ; 5α-androstanedione ; 11K-3α-adiol ; 11-keto-5α-androstane-3α ; 17β-diol ; 11K-5α-dione ; 11-keto5α-androstanedione ; 11KA4 ; 11-ketoandrostenedione ; 11KAST ; 11-ketoandrosterone ; 11KDHT ; 11-ketodihydrotestosterone ; 11KepiAST ; 11-ketoepiandrosterone ; 11KT ; 11-ketotestosterone ; 11OH-5α-dione ; 11β-hydroxy-5α-androstanedione ; 11OHA4 ; 11β-hydroxyandrostenedione ; 11OHAST ; 11β-hydroxyandrosterone ; 11OHDHT ; 11β-hydroxydihydrotestosterone ; 11OHepiAST ; 11β-hydroxyepia
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：1031
- 期：Complete
- 页码：131-138
- 全文大小：722 K
文摘
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A high throughput UPC2-MS/MS method for the analysis of 19 steroids is described.
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UPC2-MS/MS offers superior selectivity and increased chromatographic efficiency.
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Significant improvements in sensitivity were achieved by UPC2-MS/MS.
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UPC2-MS/MS is a SFC based technology which is ideal for steroid analysis.