Unexplained fetal loss: the fetal side of thrombophilia
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- 作者：Andrea Luigi Tranquilli ; Franca Saccucci ; Stefano Raffaele Giannubilo ; Monia Cecati ; Linda Nocchi ; Sara Lorenzi ; Monica Emanuelli
- 关键词：IUFD ; thrombophilia ; placenta ; MTHFR ; PAI-1 ; factor V ; factor H
- 刊名：Fertility and Sterility
- 出版年：2010
- 出版时间：June 2010
- 年：2010
- 卷：94
- 期：1
- 页码：378-380
- 全文大小：72 K
文摘
Carrier status of the fetus for factor V polymorphism or double homozygosity for mutant alleles of the PAI-1 4 G/4 G and MTHFR T677 T polymorphisms must be considered risk factors for intrauterine fetal death. The clinical implications of these data need to be addressed in a prospective study to confirm our preliminary data and to answer the question of whether or not double homozygous individuals should be treated with low molecular-weight heparin and/or low-dose aspirin.