Neuroprotective effects of stemazole in the MPTP-induced acute model of Parkinson’s disease: Involvement of the dopamine system
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- 作者：Zhirui Guoa ; 1 ; Shasha Xua ; 1 ; Na Dua ; Jia Liua ; Yiyun Huangb ; Mei Hana ; hanmei@bnu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Parkinson&rsquo ; s disease ; Stemazole ; Neuroprotection ; Dopamine system ; Oxidative stress ; MPTP
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：11 March 2016
- 年：2016
- 卷：616
- 期：Complete
- 页码：152-159
- 全文大小：2290 K
文摘
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Stemazole has a protective effect against MPTP-induced neuronal damage.
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The protective effect of Stemazole appears to be related to the DA system.
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Treatment with the high dose Stemazole returned both TH and DAT to normal levels.
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Stemazole increased levels of DA and its metabolites in the striatum.
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Stemazole treatment leads to enhanced anti-oxidative capacity.