Pias1 is essential for erythroid and vascular development in the mouse embryo
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- 作者：Jerfiz D. Constanzoa ; Mi Dengb ; Smita Rindhea ; Ke-jing Tanga ; c ; Cheng-cheng Zhangb ; Pier Paolo Scaglionia ; Pier.Scaglioni@UTSouthwestern.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pias1 ; Fetal erythropoiesis ; Angiogenesis ; Yolk sac capillary plexus ; Embryonic development
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：415
- 期：1
- 页码：98-110
- 全文大小：19217 K
文摘
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Pias1 loss causes embryonic death between E9.5 and 12.5.
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Pias1 ablation leads to embryonic growth retardation and promotes cell death in vivo and in vitro.
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Pias1 is necessary for erythropoiesis and angiogenesis in the yolk sac.
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Pias1 promotes proper vascular development in the embryo proper.
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Pias1 ablation in endothelial cells recapitulates hematopoietic and angiogenic defects in the yolk sac.