Rosuvastatin enhances anti-inflammatory and inhibits pro-inflammatory functions in cultured microglial cells
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- 作者：D. Kataa ; I. Fö ; ldesib ; L.Z. Feherc ; L. Hackler Jr.c ; L.G. Puskasc ; K. Gulyaa ; gulyak@bio.u-szeged.hu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AD ; Alzheimer&rsquo ; s disease ; Cd ; cluster of differentiation ; CNS ; central nervous system ; DIV ; days in vitro ; DMEM ; Dulbecco&rsquo ; s Modified Eagle&rsquo ; s Medium ; E18 ; embryonic day 18 ; EAE ; experimental autoimmune encephalomyelitis ; ELISA ; enzyme-linked immunosorbent assay ; FBS ; fetal bovine serum ; GAPDH ; glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12) ; Iba1 ; ionized calcium-binding adaptor molecule 1 ; IL ; interleukin ; LPS ; bacterial lipopolysaccharide ; MS ; multiple sclerosis ; PBS ; ph
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：9 February 2016
- 年：2016
- 卷：314
- 期：Complete
- 页码：47-63
- 全文大小：2017 K
文摘
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Rosuvastatin was tested in unchallenged and LPS-challenged pure microglia.
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It inhibited proliferation and cell adhesion in control microglia.
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It inhibited IL-1β, TNF-α synthesis and other pro-inflammatory genes in LPS-treated cells.
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It elevated IL-10 production and the expression of other anti-inflammatory genes in both groups.
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Rosuvastatin’s effects are beneficial during neuroinflammation.