Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons
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- 作者：Teresa Rodrí ; guez-Martí ; na ; teresa.rodriguez@kcl.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Amy M. Poolera ; 1 ; amy.pooler@rd.nestle.com" class="auth_mail" title="E-mail the corresponding author ; Dawn H.W. Laua ; dawn.lau@kcl.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Gá ; bor M. Mó ; rotza ; gabor.morotz@kcl.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Kurt J. De Vosa ; 2 ; k.de_vos@sheffield.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Jonathan Gilleyb ; jon.gilley@babraham.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Michael P. Colemanb ; michael.coleman@babraham.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Diane P. Hangera ; diane.hanger@kcl.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：DIV ; days in vitro ; E18 ; embryonic day 18 ; EGFP ; enhanced green fluorescent protein ; GSK-3 ; glycogen synthase kinase-3 ; PBS ; phosphate-buffered saline ; PP ; protein phosphatase ; SDS ; sodium dodecyl sulphate
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：85
- 期：Complete
- 页码：1-10
- 全文大小：1089 K
文摘
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Expression of P301L tau reduces the number of axonal mitochondria in mice.
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Motile mitochondria exhibit increased volume in axons of neurons with P301L tau.
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P301L tau expressed in knockin mice is hypophosphorylated.
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The P301L tau mutation impairs microtubule binding but does not affect tau membrane localization.