Biopersistence and translocation to extrapulmonary organs of titanium dioxide nanoparticles after subacute inhalation exposure to aerosol in adult and elderly rats

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• 作者：Laurent Gat&eacute ; ^a ; ¹ ; Cl&eacute ; mence Disdier^b ; ¹ ; Fr&eacute ; d&eacute ; ric Cosnier^a ; Franç ; ois Gagnaire^a ; J&eacute ; rô ; me Devoy^a ; Wadad Saba^c ; Emilie Brun^d ; Monique Chalansonnet^a ; ; Aloise Mabondzo^b ; ^{aloise.mabondzo@cea.fr}
• 关键词：Titanium dioxide ; Nanoparticles aerosol ; Inhalation exposure ; Biodistribution
• 刊名：Toxicology Letters
• 出版年：2017
• 出版时间：4 January 2017
• 年：2017
• 卷：265
• 期：Complete
• 页码：61-69
• 全文大小：1222 K
• 卷排序：265

文摘

Lung uptake and clearance of titanium (Ti) in young adults and elderly rats. TiO2 nanoparticles translocation to spleen, lymphnodes and liver. Delay in translocation and higher amount of Ti in spleen, liver in the elderly group.