Rab4 Orchestrates a Small GTPase Cascade for Recruitment of Adaptor Proteins to Early Endosomes
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- 作者：Ryan S. D&rsquo ; Souza1 ; Rachel Semus1 ; Emily A. Billings1 ; Corey B. Meyer1 ; Kathryn Conger1 ; James E. Casanova1 ; jec9e@virginia.edu" class="auth_mail
- 刊名：Current Biology
- 出版年：2 June 2014
- 年：2014
- 卷：24
- 期：11
- 页码：1187-1198
- 全文大小：4144 K
文摘
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Rab4 marks an early endosomal subdomain for localized adaptor protein recruitment
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Rab4 recruits Arl1, which recruits the Arf GEFs BIG1 and BIG2 to early endosomes
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BIG1 and BIG2 locally activate class I Arfs, promoting adaptor recruitment to endosomes
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Arf1 and Arf3 have nonredundant functions in adaptor protein recruitment