Retinoids and human breast cancer: in vivo effects of an antagonist for RAR-α

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• 作者：Toma ; Salvatore ; Emionite ; Laura ; Scaramuccia ; Angelo ; Ravera ; Giambattista ; Scarabelli ; Linda
• 关键词：Retinoids ; RAR-α ; selective antagonist Ro 41-5253 ; Breast cancer ; ER ; estrogen receptor ; RAR ; retinoid acid receptor ; RARE ; retinoid acid response element ; RXR ; retinoid X receptor
• 刊名：Cancer Letters
• 出版年：2005
• 出版时间：February 28, 2005
• 年：2005
• 卷：219
• 期：1
• 页码：27-31
• 全文大小：91.2 K

文摘

The aim of the present study was to evaluate the in vivo effects of the RAR-α selective antagonist Ro 41-5253 on a xenograft animal model for breast cancer. Our observations indicate a lack of toxic side effects of the drug, even when used at high dosages. It is interesting to note that using Ro 41-5253 at dosages of 10, 30 and 100mg/kg/die resulted in a slight, but significant inhibition of cell growth. The data obtained in this study represents the basis for a further evaluation of Ro 41-5253 anti-neoplastic activity on transgenic breast cancer animal models.