Apolipoprotein E limits oxidative stress-induced cell dysfunctions in human adipocytes
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- 作者：Evelyne Tarnus ; Hanny Wassef ; Jean-Franç ; ois Carmel ; Philippe Rondeau ; Marjolaine Roche ; Jean Davignon ; Lise Bernier ; Emmanuel Bourdon
- 关键词：Oxidative stress ; Human adipocytes ; Apolipoprotein E ; Antioxidant ; Obesity ; SW872
- 刊名：FEBS Letters
- 出版年：2009
- 出版时间：18 June 2009
- 年：2009
- 卷：583
- 期：12
- 页码：2042-2048
- 全文大小：586 K
文摘
Oxidative stress in adipose tissue constitutes a pathological process involved in obesity-linked metabolic disorders. Apolipoprotein E (apoE), which exhibits antioxidant properties in plasma and brain, is highly produced by adipose tissue and adipocytes. In this study, we investigated the role of apoE in the human adipocyte response to oxidative stress. We first demonstrated that apoE secretion by adipocytes was stimulated by oxidative stress. We also observed that apoE overexpression protected adipocytes from hydrogen peroxide-induced damages, by mitigating intracellular oxidation and exerting extracellular antioxidant properties. Our findings clearly show a novel antioxidant role for apoE in adipose tissue.