Antibody-Mediated Insulin Resistance: When Insulin and Insulin Receptor Act as Autoantigens in Humans

详细信息    查看全文

• 作者：Christelle Liminet ; MD^a ; ^b ; Julien Vouillarmet ; MD^a ; ^{julien.vouillarmet@chu-lyon.fr" class="auth_mail" title="E-mail the corresponding author} ; Karim Chikh ; MD^b ; ^c ; Emmanuel Disse ; MD ; PhD^a ; ^b
• 关键词：autoantibodies ; autoimmunity ; insulin ; severe insulin resistance
• 刊名：Canadian Journal of Diabetes
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：40
• 期：5
• 页码：462-465
• 全文大小：241 K

文摘

We report the case of a patient with diabetes presenting a severe insulin-resistance syndrome due to the production of insulin autoantibodies by a lymphocytic lymphoma. We describe the various mechanisms leading to the production of insulin autoantibodies and insulin receptor autoantibodies and review the therapeutic possibilities.