Gastric emptying and gastro-oesophageal reflux in children with cystic fibrosis

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• 作者：Bruno Hauser^a ; ^{bruno.hauser@uzbrussel.be" class="auth_mail" title="E-mail the corresponding author} ; Jean De Schepper^a ; Anne Malfroot^a ; Elke De Wachter^a ; Iris De Schutter^a ; Kathelijn Keymolen^b ; Yvan Vandenplas^a
• 关键词：GOR ; Gastro-oesophageal reflux ; CF ; Cystic fibrosis ; GE ; Gastric emptying ; MII-pH ; Multichannel intraluminal impedance-pH monitoring ; GEBT ; Gastric emptying breath test ; AGOR ; Acid gastro-oesophageal reflux ; DGE ; Delayed gastric emptying ; GI ; Gastrointestinal ; GORD ; Gastro-oesophageal reflux disease ; NAGOR ; Nnon-acid gastro-oesophageal reflux ; NGE ; Normal gastric emptying ; RGE ; Rapid gastric emptying ; 99mTS ; 99mTechnetium scintigraphy ; 13C-OBT ; 13C-octanoic acid breath test ; 13C-ABT ; 13C-acetate
• 刊名：Journal of Cystic Fibrosis
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：15
• 期：4
• 页码：540-547
• 全文大小：204 K

文摘

Gastro-oesophageal reflux (GOR) is common in patients with cystic fibrosis (CF). The aim of this study was to investigate the relationship between gastric emptying (GE) and GOR in children with CF.

Methods

Multichannel intraluminal impedance-pH monitoring (MII-pH) to measure GOR and GE breath test (GEBT) to measure GE were performed in 28 children with symptoms suggestive for GOR disease (GORD) (group 1). GEBT was performed in another 28 children with/without GOR symptoms who agreed to undergo GEBT but not MII-pH (group 2).

Results

In group 1, we found increased acid GOR (AGOR) in 46.4% and delayed GE (DGE) in 21.4% but no relationship between increased AGOR and DGE. There was no DGE in group 2. We found DGE in 10.7% and rapid GE in 12.5% of the whole group.

Conclusions

Almost half of the children with CF and symptoms suggestive for GORD have increased AGOR and almost a quarter has DGE. However, there was no relation between GOR and GE.