NELL-1 expression in tumors of cartilage

详细信息    查看全文

• 作者：Jia Shen^a ; ^b ; Gregory LaChaud^a ; ^b ; ^c ; Swati Shrestha^a ; ^b ; Greg Asatrian^a ; ^b ; Xinli Zhang^a ; Sarah M. Dry^b ; Chia Soo^d ; ^e ; Kang Ting^a ; Aaron W. James^a ; ^b ; ^e ; ^f ; ^{Awjames@mednet.ucla.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Nell-1 ; Enchondroma ; Chondrosarcoma ; Osteosarcoma ; Chondroblastic osteosarcoma
• 刊名：Journal of Orthopaedics
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：12
• 期：supp_S2
• 页码：S223-S229
• 全文大小：1829 K

文摘

NELL-1 is a novel osteochondral differentiation factor protein with increasing usage in tissue engineering. Previously, we reported the expression patterns of NELL-1 in bone-forming skeletal tumors. With increasing interest in the use of NELL-1 protein, we sought to examine the expression of NELL-1 in cartilage-forming tumors.

Methods

Immunohistochemical expression was examined in human pathologic specimens.

Results

Consistent NELL-1 overexpression across all cartilage-forming tumors was observed. Similar degrees of expression were observed in enchondroma, chondrosarcoma, and chondroblastic osteosarcoma. NELL-1 expression did not significantly vary by tumor grade.

Conclusion

In summary, NELL-1 demonstrates reliable and consistent expression across cartilage-forming skeletal tumors.