Conditional deletion of IGF-I in osteocytes unexpectedly accelerates bony union of the fracture gap in mice
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- 作者：K.-H. William Laua ; b ; Charles H. Rundleb ; Xiao-Dong Zhoua ; David J. Baylinka ; Matilda H.-C. Shenga ; MSheng@llu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Fracture repair ; Insulin-like growth factor-I ; Osteocytes ; Conditional deletion ; Intramembranous bone formation ; Endochondral bone remodeling ; Bony union ; Transgenic mice
- 刊名：Bone
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：92
- 期：Complete
- 页码：18-28
- 全文大小：1896 K
文摘
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Osteocyte Igf1 cKO mice formed smaller calluses with less cartilage but more bony tissue than wild-type littermates.
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Conditional deletion of Igf1 in osteocytes promoted remodeling of endochondral bone during fracture repair.
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Conditional deletion of Igf1 in osteocytes accelerated bony union of the fracture gap.
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The accelerated bony union was associated with suppression of Sost expression and increased Bmp2 expression at the fracture site.
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Accelerated bony union in osteocyte Igf1 cKO mice was due to upregulation of Wnt signaling, which favors intramembranous bone repair.