The effects of first-line anti-tuberculosis drugs on the actions of vitamin D in human macrophages

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• 作者：Supavit Chesdachai ; Susu M. Zughaier ; Li Hao ; Russell R. Kempker ; Henry M. Blumberg ; Thomas R. Ziegler ; Vin Tangpricha ; ^{vin.tangpricha@emory.edu}
• 关键词：Vitamin D ; Tuberculosis ; Cathelicidin ; Antibiotics
• 刊名：Journal of Clinical & Translational Endocrinology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：6
• 期：Complete
• 页码：23-29
• 全文大小：978 K
• 卷排序：6

文摘

Vitamin D has a stimulatory effect on the mRNA expression of cathelicidin in vitro. Anti-TB drugs abolish the vitamin D stimulatory effect of cathelicidin in vitro. Subjects taking anti-TB drugs have no enhanced cathelicidin response to vitamin D. Anti-TB drugs may alter the vitamin D stimulatory effect on anti-microbial peptides.