Endocytosis and trafficking of BMP receptors: Regulatory mechanisms for fine-tuning the signaling response in different cellular contexts
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- 作者：Marcelo Ehrlich ; marceloe@post.tau.ac.il" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：Bone morphogenetic proteins ; Transforming growth factor-β ; Clathrin mediated endocytosis ; Membrane microdomains ; Endosomal signaling
- 刊名：Cytokine & Growth Factor Reviews
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：27
- 期：Complete
- 页码：35-42
- 全文大小：831 K
文摘
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TGF-β and BMP receptors localize to different membrane microdomains.
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TGF-β and BMP receptors internalize mainly through clathrin mediated endocytosis.
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Following endocytosis BMP receptors are sorted to one of three destinies with differing functional significance: endosomal trafficking, lysosomal degradation, or recycling to plasma membrane.