We report here the first analysis of lncRNA landscape during muscle development.
lncMD is a muscle-specific lncRNA which is tightly regulated during myogenesis.
lncMD promotes muscle differentiation by acting as a ceRNA for miR-125b.
IGF2 is an important target of miR-125b in bovine myogenesis.
lncMD increases IGF2 expression in a miR-125b-dependent manner.