DNA damage and repair kinetics of the Alternaria mycotoxins alternariol, altertoxin II and stemphyltoxin III in cultured cells
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- 作者：Stefanie C. Fleck ; Friederike Sauter ; Erika Pfeiffer ; Manfred Metzler ; Andrea Hartwig ; Beate Kö ; berle ; beate.koeberle@kit.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AME ; alternariol 9-O-methyl ther ; AOH ; alternariol ; AP ; apurinic/apyrimidinic ; ATX II ; altertoxin II ; DMEM ; Dulbecco&rsquo ; s modified eagle medium ; DMSO ; dimethyl sulfoxide ; DSB ; DNA double strand break ; FCS ; fetal calf serum ; Fpg ; formamidopyrimidine-DNA glycosylase ; HPRT ; hypoxanthine guanine phosphoribosyl transferase ; NER ; nucleotide excision repair ; PBS ; phosphate buffered saline ; PE ; plating efficiency ; SSB ; DNA single strand break ; STTX III ; stemphyltoxin III ; T4 Endo V ; T4 endonuclease V
- 刊名：Mutation Research/Genetic Toxicology and Environmental Mutagenesis
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：798-799
- 期：Complete
- 页码：27-34
- 全文大小：810 K
文摘
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Stemphyltoxin III has a 40-fold higher mutagenicity than alternariol in V79 cells.
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Different mechanism of genotoxicity have been established for the mycotoxins.
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Altertoxin II and stemphyltoxin III induce Fpg-sensitive DNA damage.
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Repair of stemphyltoxin III-induced DNA damage depends on nucleotide excision repair.