Neurotrophin Signaling Is Required for Glucose-Induced Insulin Secretion
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- 作者：Jessica Houtz1 ; Philip Borden1 ; 3 ; Alexis Ceasrine1 ; Liliana Minichiello2 ; Rejji Kuruvilla1 ; 4 ; rkuruvilla@jhu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：neurotrophins ; glucose homeostasis ; pancreatic vasculature ; insulin secretion ; actin remodeling ; endosomal signaling ; human islets ; pericytes
- 刊名：Developmental Cell
- 出版年：2016
- 出版时间：7 November 2016
- 年：2016
- 卷：39
- 期：3
- 页码：329-345
- 全文大小：5564 K
文摘
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Glucose acutely stimulates NGF secretion and signaling in the pancreas
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Vascular NGF and β cell TrkA receptors are essential for glucose homeostasis
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Internalized TrkA receptors promote insulin exocytosis via F-actin reorganization
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NGF augments glucose-stimulated insulin secretion in human islets