Sibutramine provokes apoptosis of aortic endothelial cells through altered production of reactive oxygen and nitrogen species

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• 作者：Yoshifumi Morikawa^a ; Akinobu Shibata^b ; Naoko Okumura^b ; Akira Ikari^b ; Yasuhide Sasajima^a ; Koichi Suenami^a ; Kiyohito Sato^a ; Yuji Takekoshi^a ; Ossama El-Kabbani^c ; Toshiyuki Matsunaga^b ; ^{matsunagat@gifu-pu.ac.jp}
• 关键词：Sibutramine ; Endothelial cell ; Apoptosis ; Reactive oxygen species ; Nitric oxide
• 刊名：Toxicology and Applied Pharmacology
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：314
• 期：Complete
• 页码：1-11
• 全文大小：1790 K
• 卷排序：314

文摘

Treatment with sibutramine, an anorexiant, induces endothelial cell apoptosis. The apoptotic mechanism includes induction of ROS and NO depletion. There is an inverse relationship between sibutramine cytotoxicity and its metabolism.