VEGF-A/Notch-Induced Podosomes Proteolyse Basement Membrane Collagen-IV during Retinal Sprouting Angiogenesis
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- 作者：Pirjo Spuul1 ; 2 ; 4 ; 5 ; Thomas Daubon1 ; 4 ; 6 ; Bettina Pitter3 ; Florian Alonso1 ; 2 ; Isabelle Fremaux1 ; 2 ; IJsbrand Kramer1 ; 2 ; Eloi Montanez3 ; eloi.montanez@med.uni-muenchen.de" class="auth_mail" title="E-mail the corresponding author ; Elisabeth Gé ; not1 ; 2 ; 7 ; elisabeth.genot@inserm.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：cytoskeleton ; actin ; VEGF-A ; Notch/Dll4 signaling ; podosomes ; tip cells ; angiogenesis ; retina ; basement membrane ; collagen-IV
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：4 October 2016
- 年：2016
- 卷：17
- 期：2
- 页码：484-500
- 全文大小：8833 K
文摘
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Endothelial cells form podosomes during developmental physiological angiogenesis
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Podosome formation coincides with loss of collagen-IV vessel coverage
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The VEGF/Notch pathway regulates podosome formation in endothelial cells
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The microenvironment regulates podosome arrangement in angiogenic endothelial cells