Partial contribution of the Keap1-Nrf2 system to cadmium-mediated metallothionein expression in vascular endothelial cells
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- 作者：Yasuhiro Shinkaia ; Tomoki Kimurab ; Ayaka Itagakic ; Chika Yamamotoc ; d ; Keiko Taguchie ; Masayuki Yamamotoe ; Yoshito Kumagaia ; yk-em-tu@md.tsukuba.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Toshiyuki Kajic ; f ; t-kaji@rs.tus.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cadmium ; Keap1 ; Nrf2 ; Metallothionein ; Antioxidant response element
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：295
- 期：Complete
- 页码：37-46
- 全文大小：1270 K
文摘
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Role of the Keap1–Nrf2 system in cellular response to cadmium was examined.
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We used bovine aortic endothelial cells as a model of the vascular endothelium.
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Exposure of cells to cadmium resulted in modification of Keap1 and Nrf2 activation.
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Keap1–Nrf2 system participated in the modulation of metallothionein-1/2 expression.
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Nrf2 was recruited to the antioxidant response element of MT2 promoter region.