Quercetin inhibits LPS-induced adhesion molecule expression and oxidant production in human aortic endothelial cells by p38-mediated Nrf2 activation and antioxidant enzyme induction
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- 作者：Chuan Li ; Wei-Jian Zhang ; Balz Frei ; balz.frei@oregonstate.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AP-1 ; activator protein 1 ; DCFH-DA ; 2&prime ; 7&prime ; -dichlorofluorescin diacetate ; E-selectin ; endothelial-leukocyte adhesion molecule-1 ; EGCG ; epigallocatechin gallate ; FBS ; fetal bovine serum ; GCL ; glutamate-cysteine ligase ; GCLC ; glutamate-cysteine ligase catalytic subunit ; GCLM ; glutamate-cysteine ligase modifier subunit ; HAEC ; human aortic endothelial cells ; HO-1 ; heme oxygenase-1 ; ICAM-1 ; intercellular adhesion molecule-1 ; LPS ; lipopolysaccharide ; NF-κB ; nuclear factor-kappaB ; NQO1 ; NAD(P
- 刊名：Redox Biology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：9
- 期：Complete
- 页码：104-113
- 全文大小：857 K
文摘
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Quercetin inhibits LPS-induced oxidant production and adhesion molecule expression.
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Quercetin activates p38 MAP kinase and Nrf2, upregulating heme oxygenase-1 (HO-1).
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HO-1 rather than NF-κB may account for quercetin’s anti-inflammatory effects.