Hypoxic stress up-regulates Kir2.1 expression and facilitates cell proliferation in brain capillary endothelial cells
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- 作者：Hideto Yamamuraa ; Yoshiaki Suzukia ; Hisao Yamamuraa ; Kiyofumi Asaib ; Yuji Imaizumia ; yimaizum@phar.nagoya-cu.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Brain endothelial cells ; Cell proliferation ; Hypoxia ; Kir2.1 channel ; Store-operated Ca2+ entry
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：5 August 2016
- 年：2016
- 卷：476
- 期：4
- 页码：386-392
- 全文大小：1295 K
文摘
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Hypoxic culture of brain endothelial cells (BEC) caused membrane hyperpolarization.
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This hyperpolarization was due to the increased expression of Kir2.1 channels.
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Hypoxia enhanced store-operated Ca2+ (SOC) entry via Kir2.1 up-regulation.
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Expression levels of putative SOC channels were not affected by hypoxia.
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Kir2.1 up-regulation is responsible for hypoxia-enhanced BEC proliferation.