Serum Endocan Correlated With Stage of Chronic Kidney Disease and Deterioration in Renal Transplant Recipients

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• 作者：Y.-H. Su^c ; K.-H. Shu^a ; ^e ; C.-P. Hu^c ; ^d ; C.-H. Cheng^a ; ^e ; M.-J. Wu^a ; ^e ; T.-M. Yu^a ; Y.-W. Chuang^a ; S.-T. Huang^a ; C.-H. Chen^a ; ^b ; ^c ; ^{cschen920@yahoo.com" class="auth_mail}
• 刊名：Transplantation Proceedings
• 出版年：March, 2014
• 年：2014
• 卷：46
• 期：2
• 页码：323-327
• 全文大小：517 K

文摘

Earlier detection and intervention for chronic renal allograft injury (CRAI) remain major challenges for transplantation physicians. Endocan plays a key role in the regulation of cell adhesion, inflammatory disorders, and tumor progression. We conducted this cross-sectional study of 97 renal transplant (RT) recipients with mean RT duration of 7.0 卤 5.7 years to determine whether Endocan could be a diagnostic and prognostic marker. The patients' mean age was 43.6 卤 13.2 years, and 55.7% (54/97) were male. Higher Endocan levels were found in more advanced chronic kidney disease (CKD) stages in a dose-dependent manner. Interestingly, the Endocan聽鈮?43.19 pg/mL group had higher creatinine (Cr; 1.2 卤 0.4 vs 1.6 卤 1.1 mg/dL; P聽= .029) and lower estimated glomerular filtration rate (eGFR; 67.8 卤 23.8 mL/min vs 54.4 卤 22.0; P聽= .006) than the Endocan聽<643.19 pg/mL group after 3 months of follow-up, respectively. Linear regression analysis found tumor necrosis factor (TNF)-伪 correlated well with Endocan. To elucidate the response of endothelium activation, we stimulated human umbilical vein endothelial cells (HUVECs) with TNF-伪 in聽vitro, and found the levels of Endocan (P聽= .022) and transforming growth factor (TGF)-尾1 (P聽= .034) increased with time, but interleukin (IL)-10 decreased (P聽= .013). In summary, Endocan may reflect the degree of endothelial cell injury in renal allografts, and showed a trend of elevation in late-stage CKD. An in聽vitro study demonstrated TNF-伪-activated HUVECs secreted high levels of Endocan and TGF-尾1, which could lead to a better understanding of the role of endothelium in immune balance. In聽conclusion, Endocan may have potential as a useful long-term indicator of CRAI in RT recipients, but further study is needed to verify our findings.