Periosteum tissue engineering in an orthotopic in vivo platform

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• 作者：J.G. Baldwin^a ; F. Wagner^a ; ^b ; ^c ; L.C. Martine^a ; B.M. Holzapfel^a ; ^d ; C. Theodoropoulos^a ; O. Bas^a ; F.M. Savi^a ; C. Werner^e ; E.M. De-Juan-Pardo^a ; ¹ ; D.W. Hutmacher^a ; ^f ; ¹ ; ^{dietmar.hutmacher@qut.edu.au}
• 关键词：Periosteum ; Tissue engineering & regenerative medicine ; Melt electrospinning writing ; Star-PEG heparin hydrogel ; Mesenchymal stem cells ; Human umbilical vein endothelial cells
• 刊名：Biomaterials
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：121
• 期：Complete
• 页码：193-204
• 全文大小：5151 K
• 卷排序：121

文摘

Human BM-MSCs transplanted within a star-PEG Heparin hydrogel carrier retained their undifferentiated phenotype in vivo. Human endothelial cells developed into mature functional vessels and connected to host vasculature. The orthotopic xenograft model provides a suitable platform to study human tissue engineered periosteal constructs.