NO-mediated anticontractile effect of the endothelium is abolished in coronary arteries of adult rats with antenatal/early postnatal hypothyroidism

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• 作者：Dina K. Gaynullina^a ; ^b ; ^c ; ¹ ; ^{dina.gaynullina@gmail.com} ; Svetlana I. Sofronova^a ; ^b ; ¹ ; Ekaterina K. Selivanova^a ; Anastasia A. Shvetsova^a ; ^b ; Anna A. Borzykh^b ; Anna P. Sharova^b ; Daria S. Kostyunina^a ; ^b ; Andrey A. Martyanov^a ; ^b ; Olga S. Tarasova^a ; ^b
• 关键词：Coronary arteries ; Development ; Nitric oxide ; 6-propyl-2-thiouracil ; Thyroid hormones ; Endothelium
• 刊名：Nitric Oxide
• 出版年：2017
• 出版时间：28 February 2017
• 年：2017
• 卷：63
• 期：Complete
• 页码：21-28
• 全文大小：870 K
• 卷排序：63

文摘

Antenatal hypothyroidism results in coronary functional remodeling in adulthood. Arteries of previously hypothyroid adult rats develop strong contractile responses. The reason for such hypercontractility is endothelial failure. Endothelial failure is due to low NO-bioavailability.