The Various Metabolic Sources of Histone Acetylation

详细信息    查看全文

• 作者：Carlos Sebastiá ; n¹ ; ² ; Raul Mostoslavsky¹ ; ² ; ³ ; ^{rmostoslavsky@mgh.harvard.edu}
• 刊名：Trends in Endocrinology & Metabolism
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：28
• 期：2
• 页码：85-87
• 全文大小：523 K
• 卷排序：28

文摘

Glucose-derived acetyl-CoA levels directly impact histone acetylation, linking the energetic status of the cell to its epigenome. Two recent reports showed that other carbon sources can contribute to the acetyl-CoA pool used for histone acetylation, highlighting the metabolic plasticity that allows cells to respond to nutrient availability.