A MEDLINE search was conducted for studies with the words 鈥渟tereotactic surgery鈥?and 鈥渆pilepsy.鈥?Post-operative results for 619 patients with stereotactic brain lesions targeting various anatomical foci were standardized using a modified Engel scale (1 鈥榝ree of seizures鈥?to 3 鈥榥o significant improvement鈥?. Each individual patient was entered into a database as a unique data point.<h4 class="h4">Resultsh4>
There was a statistically significant difference in reported seizure control among the different procedures and seizure types. The procedures that produced the best seizure control outcomes were the hippocampectomy, pallido-amygdalotomy, and amygdalohippocampectomy. Simple partial motor and combined generalized tonic clonic with complex partial seizure types demonstrated the best outcomes following surgery; complex partial and generalized tonic had the worst outcomes.<h4 class="h4">Conclusionsh4>
The results of this study demonstrate the location of brain lesions has a significant effect on seizure control. Thus, future research designed to optimize brain stimulation targets for epilepsy control may be informed by previous ablative outcomes.